Introduction: Unusual Enzymology in Natural Product Synthesis

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

“ Metathesis in Natural Product Synthesis ”

Institute of Organic Chemistry, Romanian Academy, 202B Spl. Independentei, PO Box 35-108, 060023 Bucharest, Romania; E-mail: *vdragutan@yahoo.com; **idragutan@yahoo.com “Metathesis in Natural Product Synthesis” subtitled ‘Strategies, Substrates and Catalysts’ benefits from a foreword by Robert H. Grubbs, joint recipient of the 2005 Nobel Prize in Chemistry for his work on the development of the...

متن کامل

Natural Product Synthesis

The Lycopodium alkaloids are a family of structurally complex natural products, which have provoked long-term interests in their total syntheses because of their unique and fascinating architectures and potential biological activities. In particular, fawcettimine-type Lycopodium alkaloids, such as fawcettimine (1) and fawcettidine (2) (Scheme 1), have attracted broad attention from the syntheti...

متن کامل

Cascade polycyclisations in natural product synthesis.

The efficient, stereocontrolled construction of polycyclic ring systems has long presented a formidable challenge to synthetic chemists. Cascade reactions offer a 'quick fix'--building multiple rings in a single step--and often dramatically shorten a synthetic route. In this Emerging Area article, a selection of the most recent and impressive examples of applications of this tactic to natural p...

متن کامل

Synthesis of natural product-inspired compound libraries

An important aim in biology research is the elucidation of the role of proteins in complex, dynamic biological systems through the selective perturbation of their function. In contrast to genetic perturbations, chemical perturbations of protein function are conditional, acute, easily tuneable and reversible. [1] Furthermore, drug development still largely depends on the availability of bioactiv...

متن کامل

o-quinodimethanes for natural product synthesis

Photolysis of 1-o—toluyl-3,4-dihydroisoquinolines gives protoberberine alkaloids through the intermediacy of x-hydroxy quinodimethanes and spirobenzyl isoquinol ines. Ortho trimethylsilylmethyl benzoyl chlorides on treatment with fluoride ions afford ketene quinodimethanes which can be trapped with reactive dienophiles. The reactivity pattern of these intermediates is considered in terms of the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chemical Reviews

سال: 2017

ISSN: 0009-2665,1520-6890

DOI: 10.1021/acs.chemrev.7b00124